The origins of the IFAC Symposium on System, Structure and Control goes back to the IFAC workshops first held in Prague, Czech Republic in 1989 and 1992 and subsequently in Nantes, France in 1995 and 1998 as conferences. The meeting returned to Prague in 2001, as an IFAC symposium, and, its 2nd Edition was held in Oaxaca, Mexico, in 2004. For the first time, the present meeting will be held in Brazil.